Background: The cause of obesity is an imbalance between the number of calories taken and the
amount burned. Obesity is a complex disease. The FTO rs9939609 gene polymorphism is one of the
genetic factors that contribute to obesity in addition to environmental factors. Numerous researches
have suggested a connection between the prevalence of obesity and the FTO rs9939609 gene
polymorphism
Aims: The purpose of this study is to ascertain how the FTO rs9939609 gene polymorphism relates to
the prevalence of adult obesity.
Methods: At the Biomolecular and Genetics Laboratory of the UGJ Faculty of Medicine, an analytical
observational study using a case-control design was carried out with 84 participants, 42 subjects in case
group, and 42 subjects in control groups. Data were collected utilizing DNA from blood collection, PCRRFLP for genotyping, and 2.5% electrophoretic gel for visualization. Chi-square was used for data
analysis.
Results: Findings showed that there is no link between the FTO rs9939609 polymorphism and the
prevalence of obesity (p>0.05, OR=0.710).
Conclusion: In the Indonesian population, the FTO rs9939609 gene polymorphism is not associated with
an increased risk of obesity.
Keywords: FTO polymorphism rs9939609, Obesity, Adult