Abstract. Insulin resistance is an important aspect of metabolic endocrine disorder, and
adiponectin functions as an insulin-sensitizer. Changes in adiponectin levels are associated with
alterations in insulin sensitivity. Insulin resistance results from various variables that contributes
to abnormalities in insulin signaling, including a decrease in adiponectin levels. Genetics is
recognized as one of the key elements influencing adiponectin levels, with investigations showing
that ADIPOQ SNP can impact insulin sensitivity and plasma adiponectin levels. Therefore, this study
aimed to examine association between ADIPOQ gene polymorphism in patients with type 2 diabetes
mellitus (DM) and insulin resistance level. A case-control study was conducted with 60 participants
recruited from Sunyaragi Community Health Center in Cirebon, West Java. Data were collected using
fasting blood glucose (mg/dl) and Polymerase Chain Reaction – Restriction Fragment Length
Polymorphism (PCR-RFLP). The results showed that the genotype frequency of SNP in the case
group was GG = 12 (40%), GT = 16 (53.33%), TT = 2 (6.67%). Meanwhile, in the control group, it
was observed to be GG = 18 (60%), GT = 11 (36.67%), and TT = 1 (3.33%). Statistically analysis
showed a significant association between +276 G/T polymorphism and type 2 DM. This concluded
that individuals with polymorphism are at higher risk of developing type 2 DM.
Keywords: Adiponectin; ADIPOQ; Insulin Resistance; SNP