Abstract: A company is an entity that has an important role in producing goods or services to achieve profit. In order to achieve goals and success, attention to human resource management (HR) is mandatory. Employees, as the main element in carrying out the company's duties and functions, need to be given attention to improve their performance and productivity. Factors that influence work productivity include work motivation and work-life balance. Work motivation is a driving force for individuals to achieve, while work-life balance helps avoid conflicts between work and personal life that can hinder productivity. This study aims to analyze the effect of work motivation and work-life balance on employee work productivity at the Cirebon City Health Office. The research method used is quantitative with a descriptive approach and applies multiple linear regression analysis. The results of the study indicate that both variables have a positive and significant effect on employee work productivity, both partially and simultaneously. Therefore, companies need to pay more attention to these factors to increase employee productivity, which in turn supports the achievement of company goals.