This study seeks to determine how employee performance at Manufacturing Companies in Cirebonis affected by organizational culture and job satisfaction. Descriptive correlation research using quantitative techniques is the methodology used in this study. All 100 employeesof Manufacturing Companies in Cirebonconstituted the study population, which was selected using a direct random sampling technique. Employee performance, job satisfaction, and organizational culture questionnaires provided the data. Multiple linear regression analysis is the method used to analyze the data in this study. Based on the results of Multiple Linear Regression analysis with t-testand F-test, this study concludes that employee performance is influenced by organizational culture within Manufacturing Companies in Cirebon. Job satisfaction affects the performance of Manufacturing Companies in Cirebonemployees. Job satisfaction and organizational culture affect the performance of Manufacturing Companies in Cirebonemployees. Organizational culture and job satisfaction affect employee performance at Manufacturing Companies in Cirebonby 29.8%