Latar Belakang: Coronavirus Disease (Covid-19) adalah penyakit menular yang disebabkan oleh Coronavirus Disease jenis baru, virus ini membentuk molekul virus RNA positif yang berbentuk seperti mahkota yang dapat dilihat dari mikroskop Elektron, virus ini berukuran kecil (60-140nm). Menurut WHO mengelompokkan virus SARSCoV-2 menjadi dua kategori, yaitu variant of interest (VOI) dan variant of concern (VOC). Kategori VOI diberikan jika terdapat mutasi baru dengan implikasi fenotipenya dan dapat menjadi VOC.
Tujuan: Tujuan penelitian ini bertujuan untuk menganalisis Hubungan Pengetahuan Masyarakat terhadap Kepatuhan Protokol Covid-19 di wilayah kerja Puskesmas Jalaksana Kabupaten Kuningan.
Metode: Penelitian ini merupakan penelitian penelitian observasional analitik dengan desain cross sectional. Pengambilan data pada penelitian ini dilakukan di wilayah desa Jalaksana kabupaten Kuningan dengan jumlah sampel sebanyak 508 orang.
Hasil: Hasil analisis uji komparasi Chi Square menunjukkan p-value sebesar 0,000 < 0,050, sehingga terdapat hubungan yang bermakna antara hubungan pengetahuan masyarakat terhadap kepatuhan protokol Covid-19 di wilayah kerja puskesmas Jalaksana kabupaten Kuningan. Nilai Odds ratio sebesar 19,024 berarti responden dengan pengetahuan baik memiliki kecenderungan patuh sebesar 19,024 atau 19 kali lebih besar dibandingkan dengan responden dengan pengetahuan kurang.
Simpulan: Terdapat hubungan yang bermakna antara hubungan pengetahuan masyarakat terhadap kepatuhan protokol Covid-19 di wilayah kerja puskesmas Jalaksana kabupaten Kuningan.

Kata Kunci : covid-19, pengetahuan, kepatuhan terhadap protokol Covid-19.

Background: Coronavirus Disease (Covid-19) is an infectious disease caused by a new type of Coronavirus Disease, this virus forms a positive RNA virus molecule that is shaped like a crown that can be seen from an electron microscope, this virus is small (60-140nm). According to WHO, the SARS-CoV-2 virus is classified into two categories, namely variant of interest (VOI) and a variant of concern (VOC). The VOI category is given if there is a new mutation with implications for its phenotype and can become a VOC.

Destinations: The purpose of this study was to analyze the relationship between public knowledge and compliance with the Covid-19 protocol in the work area of the Jalaksana Health Center, Kuningan Regency.

Method: This research is analytic observational research with a cross-sectional design. Data collection in this study was carried out in, Jalaksana village, Kuningan district with a total sample of 508 people.

Results: The results of the Chi Square comparative test analysis showed a p-value of 0.000 < 0.050, so there was a significant relationship between the relationship between public knowledge and adherence to the Covid-19 protocol in the Jalaksana Public Health Center, Kuningan district. Odds ratio value of 19,024 means that respondents with good knowledge have a tendency to obey 19,024 or 19 times greater than respondents with less knowledge.

Conclusion: There is a significant relationship between the relationship between public knowledge and adherence to the Covid-19 protocol in the working area of the Jalaksana Public Health Center, Kuningan Regency.

Key words: Covid-19, Knowledge, Compliance with Covid-19 Protocol.