Latar Belakang: Salah satu tanda gejala diabetes melitus berupa peningkatan
gula darah. Kayu manis memiliki kandungan polifenol, cinamaldehid, minyak
atsiri, alkohol sinamat dan kumarin. Sedangkan daun binahong memiliki
kandungan saponin, flavonoid, alkoloid, kuinon, tritrpenoid dan asam askorbat.
Kandungan tersebut dapat menurunkan kadar gula darah yang menjadi alternatif
pengobatan herbal.
Tujuan: Menganalisis kombinasi dosis ekstrak kayu manis dan ekstrak daun
binahong terhadap penurunan gula darah pada tikus jantan galur Sprague dawley
yang hiperglikemia.
Metode: 25 ekor tikus yang telah diinduksi aloxan dosis 150mg/kgBB yang
dilarutkan dalam NaCl 0,9% yang dibagi menjadi 5 kelompok yaitu kelompok
kontrol yang diberi pakan standar, perlakuan 1 diberi kombinasi kayu manis dosis
225mg/kgBB dan ekstrak daun binahong dosis 100mg/kgBB, perlakuan 2 diberi
kombinasi kayu manis dosis 75mg/kgBB dan ekstrak daun binahong dosis
300mg/kgBB, perlakuan 3 diberi kombinasi kayu manis dosis 150mg/kgBB dan
ekstrak daun binahong dosis 200mg/kgBB dan perlakuan 4 diberi kombinasi kayu
manis dosis 300mg/kgBB dan ekstrak daun binahong dosis 400mg/kgBB. Data
yang telah diperoleh diolah menggunakan Uji Pos Hoc LSD.
Hasil: Terdapat penurunan kadar gula darah pada kelompok kontrol sebesar -30,4
mg/dl, perlakuan 1 sebesar 120 mg/dl, perlakuan 2 sebesar 146 mg/dl, perlakuan 3
sebesar 159,2 mg/dl dan perlakuan 4 sebesar 189,2 mg/dl.
Simpulan: Kombinasi ekstrak kayu manis dosis 300mg/kgBB dan ekstrak daun
binahong dosis 400mg/kgBB paling efektif dalam menurunkan gula darah tikus
putih jantan galur Sprague dawley yang dibuat hiperglikemia.
Kata Kunci: Hiperglikemi, Diabetes Melitus, Kayu Manis, Daun Binahong,
Sprague dawley, Tikus Putih

Background : One of the signs of diabetes mellitus is an increase in blood sugar.
Cinnamon contains polyphenols, cinamaldehyde, essential oils, cinnamic alcohol
and coumarins. While binahong leaves contain saponins, flavonoids, alkaloids,
quinones, tritrpenoids and ascorbic acid. This contents can lower blood sugar
levels to be an alternative herbal treatment.
Aim : To analyze the dose of cinnamon extract and binahong leaf extract
combination on reducing blood sugar in hyperglycemic male Sprague Dawley
rats.
Method : 25 rats that had been induced with 150mg/kgBW alloxan dissolved in
0.9% NaCl which were divided into 5 groups, namely the control group which
was given standard feed, treatment 1 was given a combination of cinnamon at a
dose of 225mg/kgBW and binahong leaf extract at a dose of 100mg/kgBW,
treatment 2 was given a combination of cinnamon at a dose of 75mg/kgBW and
binahong leaf extract at a dose of 300mg/kgBW, treatment 3 was given a
combination of cinnamon at a dose of 150mg/kgBW and binahong leaf extract at
a dose of 200mg/kgBW and treatment 4 was given a combination of cinnamon at a
dose of 300mg/kgBWand binahong leaf extract at a dose of 400mg/kgBW. The
data that has been obtained is processed using the LSD Post Hoc Test.
Results : There was a decrease in blood sugar levels in the control group by -30.4
mg/dl, treatment 1 by 120 mg/dl, treatment 2 by 146 mg/dl, treatment 3 by 159,2
mg/dl and treatment 4 by 189.2 mg/dl.
Conclusion : The combination of cinnamon extract at a dose of 300mg/kgBW and
binahong leaf extract at a dose of 400mg/kgBW was most effective in lowering the
blood sugar of male white rats of the Sprague Dawley strain that were made
hyperglycemic.
Keyword : Binahong Leaf, Diabetes Mellitus, Hyperglycemia, Cinnamon, Sprague
Dawley, White Rat