Latar Belakang : Penyakit ginjal kronik (PGK) adalah hilangnya fungsi ginjal progresif yang berhubungan dengan penyakit sistemik, seperti diabetes melitus dan hipertensi atau terikat dengan penyakit ginjal intrinsik, seperti gagal ginjal akut, glomerulonefritis kronik, pielonefritis kronik.
Tujuan : Mengetahui hubungan diabetes mellitus dan hipertensi dengan kejadian gagal ginjal kronik yang menjalani hemodialisis di RSUD Karawang.
Metode : Penelitian ini merupakan penelitian observasional analitik yaitu case control. Kelompok kasus 50 sampel adalah pasien PGK yang menjalani hemodialisis, sementara kelompok kontrol 50 sampel adalah pasien selain PGK. Data sekunder diperoleh melalui pengambilan data rekam medis. Analisis data yang dilakukan adalah analisis univariat, bivariat (2x2 chi-square) dan multivariat (regresi logistik).
Hasil : Analisis univariat penelitian ini mayoritas berjenis kelamin laki-laki (51,0%), mayoritas usia (50 - 59) tahun. Analisis bivariat hubungan diabetes mellitus dengan kejadian gagal ginjal kronik yang menjalani hemodialisis diperoleh nilai (p=0,027) dengan nilai OR 3,143, hubungan hipertensi dengan kejadian gagal ginjal kronik yang menjalani hemodialisis diperoleh nilai (p=0,023) dengan nilai OR 2,627, hubungan diabetes mellitus dan hipertensi dengan kejadian gagal ginjal kronik yang menjalani hemodialisis diperoleh nilai (p=0,037) dengan nilai OR 3,917. Analisis multivariat penelitian ini yang paling berpengaruh terhadap kejadian gagal ginjal kronik adalah diabetes mellitus dan hupertensi Exp(B) 42,544.
Kesimpulan : Terdapat hubungan diabetes mellitus dan hipertensi dengan kejadian gagal ginjal kronik yang menjalani hemodialisis.
Kata Kunci : Gagal ginjal kronik, hemodialisis, diabetes mellitus, hipertensi.

Backgrounds : Chronic kidney disease (CKD) is progressive kidney function associated with systemic diseases, such as diabetes mellitus and hypertension or control with intrinsic disease, such as acute renal failure, chronic glomerulonephritis, chronic pyelonephritis.
Objectives: To know the relationship between diabetes mellitus and hypertension with chronic kidney disease which undergoing hemodialysis at Karawang Hospital.
Methods : This research is a case control analytic observational study. The case group of 50 samples were CKD patients undergoing hemodialysis, while the control group 50 samples were patients other than CKD, with certain inclusion and exclusion criteria. Secondary data was obtained through the collection of medical record data. Data analysis performed was univariate, bivariate (2x2 chi-square). And multivariat analysis (regression logistical).
Result : The univariate analysis of this study was that the majority were male (51.0%), the majority were aged (50 - 59) years. Bivariate analysis of the relationship between diabetes mellitus and the incidence of chronic kidney failure undergoing hemodialysis obtained a value (p = 0.027) with an OR value of 3,143, the relationship between hypertension and the incidence of chronic kidney failure undergoing hemodialysis obtained a value (p = 0.023) with an OR value of 2,627. The relationship between diabetes mellitus and hypertension with the incidence of chronic kidney failure undergoing hemodialysis obtained a value (p = 0.037) with an OR value of 3.917. The multivariate analysis of this study that has the most influence on the incidence of chronic kidney failure is diabetes mellitus and hypertension Exp(B) 42.544.
Conclusion: There is a relationship between diabetes mellitus and hypertension the incidence of chronic kidney failure undergoing hemodialysis, there is a relationship between hypertension and the incidence of chronic renal failure undergoing hemodialysis.
Keyword : Chronic kidney disease, hemodialysis, diabetes mellitus, hypertension.