Latar belakang: Pengetahuan masyarakat khususnya dalam transmisi penularan dan pencegahan dari Covid 19 meliputi protokol Kesehatan sangat penting di masa pandemi. Penerapan protokol Kesehatan meliputi 5M yaitu, menjaga jarak, mencuci tangan, menghindari kerumunan, memakai masker, dan mengurangi mobilisasi.
Tujuan: Mengetahui hubungan karakteristik individu terhadap kepatuhan dalam penerapan 5M di masa pandemi Covid 19.
Metode: Penelitian ini merupakan penelitian observasional analitik dengan desain Cross Sectional. Sampel yang digunakan dalam penelitian ini sebanyak 389 responden. Teknik sampling yang digunakan adalah cluster random sampling. Uji statistik menggunakan uji korelasi spearman.
Hasil: Sebagian besar responden tidak patuh dalam menerapkan 5M (78,9%), dan responden yang memiliki pengetahuan baik (59,1%). Terdapat hubungan (p=0,000; r =-0,196) antara tingkat pendidikan terhadap penerapan 5M. Tidak terdapat hubungan yang signifikan antara jenis kelamin dan pekerjaan terhadap penerapan 5M (p>0,05). Hasil uji spearman menunjukkan terdapat hubungan yang signifikan antara pengetahuan terhadap kepatuhan dalam penerapan protokol kesehatan 5M dengan korelasi lemah (p=0,000; r 0,218).
Kesimpulan: Terdapat hubungan yang signifikan antara pengetahuan terhadap kepatuhan dalam penerapan protokol kesehatan 5M di masa pandemi Covid 19.
Kata Kunci: Covid 19, Pengetahuan, Penerapan 5M.

Background: Public knowledge, especially in the transmission and prevention of Covid-19 is very important during pandemic. One of the ways that can be applied to inhibit transmission during this pandemic was to apply 5M, namely, keeping the distance, washing hands, avoiding crowds, wearing masks, and reducing mobilization.
Objective: The aim of this study was to discover the relationship of knowledge to behavior in implementing 5M during the Covid-19 pandemic.
Methods: This study was an observational analytic approach with sectional cross design. The number of research samples in this study was 389 people. The sampling technique used was cluster random sampling. The statistical test in this study used the Spearman correlation test.
Results: Most of the respondents were not compliant with implementing 5M (78,9%) and have good knowledge (59,1%). There was a relationship (p = 0,000 and r = 0,-196) between education and the implementation of 5M. There was no significant relationship between gender and occupation with the application of 5M (p>0,05). The results of the Spearman test showed that there was a significant relationship between knowledge and behavior in implementation of 5M with weak correlation (p = 0,000; r 0,218).
Conclusion: This study concluded that there was a significant relationship to behavior in the implementing 5M during the Covid-19 pandemic.
Keywords: Covid-19, Knowledge, 5M implementation